@ARTICLE{BCCCMMR07,
  title = {{An Agent-based Multilayer Architecture for Bioinformatics Grids}},
  author = {Bartocci, Ezio and Cacciagrano, Diletta and Cannata, Nicola and Corradini, Flavio and Merelli, Emanuela and Milanesi, Luciano and Romano, Paolo},
  journal = {IEEE transactions on Nanobioscience},
  pages = {142-148},
  abstract = {Due to the huge volume and complexity of biological data available today, a
      fundamental component of biomedical research is now in silico analysis. This
      includes modelling and simulation of biological systems and processes, as well
      as automated bioinformatics analysis of high-throughput data. The quest for
      bioinformatics resources (including databases, tools, and knowledge) becomes
      therefore of extreme importance. Bioinformatics itself is in rapid evolution
      and dedicated Grid cyberinfrastructures already offer easier access and sharing
      of resources. Furthermore, the concept of the Grid is progressively interleaving
      with those of Web Services, semantics, and software agents. Agent-based systems
      can play a key role in learning, planning, interaction, and coordination.
      Agents constitute also a natural paradigm to engineer simulations of complex
      systems like the molecular ones. We present here an agent-based, multilayer
      architecture for bioinformatics Grids. It is intended to support both the
      execution of complex in silico experiments and the simulation of biological
      systems. In the architecture a pivotal role is assigned to an
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      semantic index of resources, which is also expected to facilitate users'
      awareness of the bioinformatics domain.},
  volume = {6},
  number = {2},
  year = {2007},
  url = {http://ieeexplore.ieee.org/},
}