@INPROCEEDINGS{GBCESW08,
title = {{Learning and Detecting Emergent Behavior in Networks of Cardiac Myocytes}},
author = {Grosu, Radu and Bartocci, Ezio and Corradini, Flavio and Entcheva, Emilia and Smolka, Scott A. and Wasilewska, Anita },
booktitle = {In the proceedings of the 11th International Conference on Hybrid Systems: Computation and Control (HSCC'08), St. Louis, USA, April, 2008},
pages = {229-243},
abstract = {We address the problem of specifying and detecting emergent behavior in networks
of cardiac myocytes, spiral electric waves in particular, a precursor to atrial
and ventricular fibrillation. To solve this
problem we: (1) Apply discrete mode-abstraction to the cycle-linear hybrid
automata (CLHA) we have recently developed for modeling the
behavior of myocyte networks; (2) Introduce the new concept of
spatial-superposition of CLHA modes; (3) Develop a new spatial logic, based on
spatial-superposition, for specifying emergent behavior; (4) Devise a new
method for learning the formulae of this logic from the spatial patterns under
investigation; and (5) Apply bounded model checking to detect (within
milliseconds) the onset of spiral waves. We have implemented our methodology as
the Emerald tool-suite, a component of our EHA framework for specification,
simulation, analysis and control of excitable hybrid automata. We illustrate
the effectiveness of our approach by applying Emerald to the scalar electrical
fields produced by our CellExcite simulator.
},
publisher = {Springer},
series = {Lectures Notes in Computer Science},
volume = {4981},
year = {2008},
}