Warning: session_start() [function.session-start]: open(/var/lib/php5/sess_a1aa75cc2c36d0b2a613e8d00ec1403b, O_RDWR) failed: Read-only file system (30) in /var/www/cosy/biblio/papers_fun.php on line 13

Warning: session_start() [function.session-start]: Cannot send session cookie - headers already sent by (output started at /var/www/cosy/biblio/papers_fun.php:13) in /var/www/cosy/biblio/papers_fun.php on line 13

Warning: session_start() [function.session-start]: Cannot send session cache limiter - headers already sent (output started at /var/www/cosy/biblio/papers_fun.php:13) in /var/www/cosy/biblio/papers_fun.php on line 13

Warning: Cannot modify header information - headers already sent by (output started at /var/www/cosy/biblio/papers_fun.php:13) in /var/www/cosy/biblio/header.php on line 2
CoSy Bibliography
Spatial Networks of Hybrid I/O Automata for Modeling Excitable Tissue
Ezio Bartocci, Flavio Corradini, Maria Rita Di Berardini, Emilia Entcheva, Radu Grosu, Scott A. Smolka.
In the proceedings of FBTC'07 From Biology to Concurrency and Back International Workshop co-sited with CONCUR conference. pp. 86-102. Electronic Notes in Theoretical Computer Science vol. 194 no. 3. Elsevier. 2007.
Abstract:
We propose a new biological framework, spatial networks of hybrid input/output automata (SNHIOA), for the efficient modeling and simulation of excitable-cell tissue. Within this framework, we view an excitable tissue as a network of interacting cells disposed according to a 2D spatial lattice, with the electrical behavior of a single cell modeled as a hybrid input/ouput automaton. To capture the phenomenon that the strength of communication between automata depends on their relative positions within the lattice, we introduce a new, weighted parallel composition operator to specify the influence of one automata over another. The purpose of the SNHIOA model is to efficiently capture the spatiotemporal behavior of wave propagation in 2D excitable media. To validate this claim, we show how SNHIOA can be used to model and capture different spatiotemporal behavior of wave propagation in 2D isotropic cardiac tissue, including normal planar wave propagation, spiral creation, the breakup of spirals into more complex (potentially lethal) spatiotemporal patterns, and the recovery of the tissue to the rest via defibrillation.
Categories: Computational Systems Biology, CoSy Group, Modelling, Simulation
@INPROCEEDINGS{BCDEGS07,
  title = {{Spatial Networks of Hybrid I/O Automata for Modeling Excitable Tissue}},
  author = {Bartocci, Ezio and Corradini, Flavio and Di Berardini, Maria Rita and Entcheva, Emilia and Grosu, Radu and Smolka, Scott A.},
  booktitle = {In the proceedings of FBTC'07 From Biology to Concurrency and Back International Workshop co-sited with CONCUR conference},
  pages = {86-102},
  abstract = {We propose a new biological framework, spatial networks of hybrid input/output
      automata (SNHIOA), for the efficient modeling and simulation of excitable-cell
      tissue.  Within this framework, we view an excitable tissue as a network of
      interacting cells disposed according to a 2D spatial lattice, with the
      electrical behavior of a single cell modeled as a hybrid input/ouput automaton.
       To capture the phenomenon that the strength of communication between automata
      depends on their relative positions within the lattice, we introduce  a new,
      weighted parallel composition operator to
      specify the influence of one automata over another.
      
      The purpose of the SNHIOA model is to efficiently capture the spatiotemporal
      behavior of wave propagation in 2D excitable media.  To validate this claim, we
      show how SNHIOA can be used to model and capture different spatiotemporal
      behavior of wave propagation in 2D isotropic cardiac tissue, including normal
      planar wave propagation, spiral creation, the breakup of spirals into more
      complex (potentially lethal) spatiotemporal patterns, and the recovery of the
      tissue to the rest via defibrillation.},
  publisher = {Elsevier},
  series = {Electronic Notes in Theoretical Computer Science},
  volume = {194},
  number = {3},
  year = {2007},
}

Warning: Unknown: open(/var/lib/php5/sess_a1aa75cc2c36d0b2a613e8d00ec1403b, O_RDWR) failed: Read-only file system (30) in Unknown on line 0

Warning: Unknown: Failed to write session data (files). Please verify that the current setting of session.save_path is correct (/var/lib/php5) in Unknown on line 0